I optimize system and remove unused process.  So I don't use wi-fi and sound card.
I see this process 
642 ?        Ss     0:10 /sbin/wpa_supplicant -u -s -O /run/wpa_supplicant

how can I disable autostart it?

systemctl disable wpa_supplicant

 

I was trying to do the same thing with my pihole running debian. Disabling the wpa_supplicant service didn't work for me because it seemed to get dragged up by polkit. Did you solve the problem?

 

The only way I could figure out to prevent wpa_supplicant from coming up was to disable network-manager entirely. Since I set my ip statically with interfaces file it's ok for me but I imagine there is a better way.

try removing /usr/share/dbus-1/system-services/fi.w1.wpa_supplicant1.service, this is probably what's polkit calling.